Backed by in-house band The Roots, the Bay Area rapper will take the stage with Detroit's Big Sean to perform Sean's catchy song "IDFWU." Other guests on the show include Jerry Seinfeld and UK boy band One Direction.
His motto used to be, "Make like a pregnant lady and come with an album every nine months," but the prolific E-40 has topped his old goals. He just released the first two of four new albums, a series called Sharp On All Four Corners. The next two installments are due early in 2015.
The Tonight Show Starring Jimmy Fallon airs right here on NBC at 11:35 p.m.