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Newcomer Jenny Slate drops the f-bomb in a sketch with veteran Kristen Wiig during the season opener.
The New York comedian will not be returning for the show's 36th season, EW confirmed.
Slate made headlines last fall when she dropped the f-bomb during her SNL debut.
The newbie was performing in "Biker Chicks Chat," playing a foulmouthed motorcycle-driving woman clad in leather, when she dropped the curse word, which slipped by censors and was heard by East Coast viewers.
Amy Poehler will host the "Saturday Night Life" premiere on Sept. 25 as four new cast members make their debut: Vanessa Bayer and Paul Brittain, both from Chicago's iO Improv Theater, Taran Killam from the Los Angeles comedy group The Groundlings, and Jay Pharoah, a comedian originally from Virginia.