Oprah's Biggest Moments

Talk show queen Oprah Winfrey has signed off for good. Among the top “Oprah” moments from the past 25 years: Tom Cruise bouncing on Winfrey’s couch to proclaim his love for Katie Holmes in 2005. Check out more surprises, scandals and milestones in Oprah's career.

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    • Oprah and Best Friend Gayle.jpg
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