The unidentified man he was driving on the upper deck of the Bay Bridge at 3:30 a.m. He lost control at the new s-curve and plunged over the side of the Bay Bridge.
His truck flipped over a traffic barrier, and fell about 200 feet below on to Yerba Buena Island.
The speed limit is 40 mph in the area and police said the driver was going 50 mph.
Safety has been an issue on the S-curve since it was put into place Labor Day weekend. Monday's crash was the 43rd since early September.
Caltrans was quick to defend the safety of the new section.
Spokesman Bob Haus said there is nothing wrong with the design, adding speed was a factor in "every single" crash.
During the bridge's recent unexpected closure, Caltrans installed reflectors and raised bumps between lanes on the S-curve so that drivers can feel the bumps when they begin to veer out of their lanes, Caltrans spokesman Bart Ney said.
Caltrans also laid down a grit surface over a steel section of the S-curve to provide better traction, Ney said.
In the next month, Caltrans said it will install additional permanent signage alerting drivers of the lower speed limit on the S-curve as well as radar signs that show drivers their speeds as they pass, Ney said.
Caltrans will also place reflective striping on the barriers along the edge of the roadway on both decks.
Monday morning's crash caused only superficial damage to the bridge, but Caltrans said it will repair some signage that was damaged sometime Monday evening.