The last ever U.S. Airways flight departed from San Francisco International Airport late Friday.
Flight 1939 left SFO at 9:55 p.m. for a return trip to Philadelphia, where it departed earlier in the day on the first leg of a journey that took the plane to Charlotte and Phoenix, SFO spokesman Doug Yakel said.
The flight is named for the year U.S. Airways' predecessor-company All American Aviation began operating, which was 1939, Yakel said.
The Airbus A321 left with 187 people on board and had a champagne toast at cruising altitude "to celebrate and honor the legacy of U.S. Airways," American Airlines spokesman Ross Feinstein said.
John and Jacqui Katchur, a couple who met on a US Airways flight, were one of the passengers onboard. The Katchurs said the final flight is something they would not miss.
Yakel and Feinstein said a lot of people wanted to be on board for the sold out historic flight.
The plane left SFO from Terminal 1, Gate 45, where passengers were able to celebrate before the flight with food and prizes, officials said.
Capt. Doug Rice will be in the cockpit for the final flight. He expects a smooth flight and transition.
"We're joining the world's largest airlines and it's gonna be wonderful for passengers, employees and the future of the company," Rice said.
The non-stop, red-eye flight is scheduled to arrive in Philadelphia at 6:18 a.m. Eastern Standard Time.
U.S. Airways and American Airlines merged two years ago, Feinstein said.
FROSCH Travel Agent Christina Turrini said merging reservation systems can create turbulence.
"United and Continental was a disaster for everyone," Turrini said.
American Airlines said it has run five million mock reservations, increasing staff on Saturday and has reduced its schedule by 200 flights.