Gore’s first touchdown run of 79 yards gave the 49ers a 10-0 lead on San Francisco’s first play of their second drive. On the first play of the second half, he blasted off for 80 yards and a score finishing with 207 yards on 16 carries.
Since 1940, the only other player to have multiple touchdown runs of more than 75 yards was Barry Sanders who did it in 1997.
Gore’s 207 yards rushing is the second-highest total in 49ers history. He ran for 212 yards in 2006, also against Seattle. He also posted just the third 200-yard rushing game in team history. Charlie Garner ran for 201 yards at Dallas on Sept. 24, 2000.
Gore, who had just 30 yards on 22 carries in the 49ers opening day win over the Cardinals, had averaged 76 yards against Seattle in the previous four meetings since his Pro Bowl 2006 season.
The 49ers are now 2-0 on both the season and versus the NFC West. San Francisco plays at Minnesota next Sunday.