They will be performing at a fundraiser or after party for the University of California at San Francisco Benioff Children's Hospital.
The location of the after-party is secret for now and will be announced at the concert.
The gig is bringing them to the Nob Hill Masonic Auditorium.
The new 183-bed hospital will be part of an integrated hospital complex for children, women and cancer patients in the city's Mission Bay neighborhood. The fundraising goal for the hospital is $600 million, and they are currently at about $375 million, according to event organizers.
The event is being organized by the Salesforce.com Foundation
Tickets cost $250 for upper rear balcony seat, $500 for balcony seating, and $1,000 for main floor seating, and can be bought at this link.