The hourlong debate at the Pasadena studio of KPCC FM will be divided into 3 1/2-minute segments. Host and Los Angeles Times columnist Patt Morrison and La Opinion Metro Editor Gabriel Lerner will alternate asking questions and follow-ups. Some of the questions may come from KPCC listeners and La Opinion readers.
The debate can be heard live from 1 p.m. to 2 p.m.
In that debate, the two candidates talked a lot about the environment and jobs. With a state unemployment rate that tops 12 percent, the jobs issue is sure to come up again Wednesday.
Boxer has criticized Fiorina's record at Hewlett-Packard.
"She shipped 30,000 jobs overseas," Boxer said during the first debate. "And through all that pain, what did she do to show any sacrifice? She took $100 million.
Fiorina countered by saying business leaders sometimes need to make difficult decisions. She said it was an "agonizing choice to lose some jobs to save more."
She said her jobs plan includes less regulation and lower taxes. The California Chamber of Commerce and the California Manufacturers and Technology Association, recently endorsed Fiorina.
In a statewide survey form the Public Policy Institute of California, respondents listed jobs as "the most import issue facing people in California today" at least three times more than non-pocketbook issues like same sex marriage, illegal immigration and off-shore drilling.
"I'm hopeful that we're going to get from these candidates their real sensibilities, their real philosophies and their practical solutions about government," Morrison told City News Service. "It's always good to get past the advertising to find out more about their thinking about how government is supposed to be run.''
Both campaigns have expressed a willingness to debate additional times, but have not been able to reach agreement on dates or locations.
A new Rasmussen survey of likely voters was released Tuesday. It showed Boxer four points ahead of challenger Fiorina, 47 percent to 43 percent with 6 percent undecided.