This was no laughing matter.
Chelsey Handler had knee surgery on Thursday, Us Weekly reported.
The funnywoman missed the night’s taping of her late-night series “Chelsea Lately, but she assured her fans via Twittter that she was doing just fine.
"Fortune Feimster will be filling in as the host on tonight's show with more photos of me and my knee making a quick recovery. Pls support her," the comic wrote on her Twitter page.
Handler also posted a snapshot of herself in a hospital bed munching on graham crackers, according to Us.
The stand-up comedian and actress delivered a pre-taped message on her Thursday broadcast, where Feimster interviewed “Real Housewives of Orange County's” Gretchen Rossi and Tamra Barney.
"I just woke up from surgery -- from my vaginal rejuvenation surgery," Handler joked about her hospital stay.
Handler did not explain why she needed the knee operation.