The California Highway Patrol was diverting traffic off of Interstate Highway 580 Friday morning following a fatal crash in San Leandro on the approach into Castro Valley.
Eastbound traffic was being diverted off the highway at the 164th Avenue off-ramp, and the CHP has issued a Sig-alert due to the crash.
The highway reopened by about 7:30 a.m.
Emergency crews responded at 4:21 a.m. to rollover crash involving at least two vehicles and with one vehicle engulfed in flames.
People injured in the crash were also transported to the hospital, officers said.
Bay City News contributed to this report.