The Raiders on Sunday head to San Diego looking to clinch a playoff spot by defeating the AFC West rival Chargers.
Oakland, however, will have to do so without three young players on defense, including first-round pick and safety Karl Joseph.
Joseph missed practice all week with a toe injury and was ruled out Friday by the team.
Edge defender Shilique Calhoun (knee) and defensive tackle Stacy McGee (ankle) were also ruled out.
Derek Carr was full go in practice and gets the start against the Chargers, a team he's 3-2 against in his career with 10 touchdowns and just three interceptions.
Raiders participation report
Did not practice: LB Shilique Calhoun (knee), S Karl Joseph (toe), DT Stacy McGee (ankle)
Limited participation: WR Amari Cooper (shoulder), WR Michael Crabtree (finger), DT Darius Latham (ankle), OL Kelechi Osemele (knee), LB Perry Riley (hamstring), LB Malcolm Smith (hamstring)
Full participation: QB Derek Carr (right finger)