Isaac Guerendo

San Francisco 49ers rookie running back Isaac Guerendo’s availability to face the Los Angeles Rams on Thursday night appears to be in question.

Rookie running back Isaac Guerendo did more than enough in San Francisco’s Week 14 win while giving the 49ers Faithful plenty to cheer about.

A glimpse of what has made the San Francisco 49ers so formidable in the past was on full display against the Chicago Bears on Sunday.

49ers rookie running back Isaac Guerendo doesn’t appear to be concerned about a foot injury that forced him to exit San Francisco’s 38-13 win over the Chicago Bears on Sunday at Levi’s Stadium.

The San Francisco 49ers dominated the Chicago Bears on Sunday behind big games from rookie Isaac Guerendo and All-Pro George Kittle.

Matt Maiocco lists five 49ers to keep an eye on in San Francisco’s must-win game against the Chicago Bears on Sunday at Levi’s Stadium.

Rookie 49ers running back Isaac Guerendo will get his shot in San Francisco’s Week 14 game against the Chicago Bears.

San Francisco 49ers coach Kyle Shanahan believes rookie running back Isaac Guerendo is ready for a feature role after recent injuries at the position.

San Francisco 49ers general manager John Lynch spoke to NBC Sports Bay Area’s Matt Maiocco on “49ers Game Plan” and explained why he anticipates a breakout performance from Christian McCaffrey.

49ers coach Kyle Shanahan and running back Christian McCaffrey explained San Francisco’s perceived lack of rotation at the position.

John Lynch revealed what Christian McCaffrey’s impending return might mean for backup San Francisco 49ers running backs Jordan Mason and Isaac Guerendo.

San Francisco 49ers rookie running back Isaac Guerendo detailed his excitement to stay ready and learn when superstar Christian McCaffrey makes his 2024 NFL season debut.

Christian McCaffrey returned to San Francisco 49ers practice on Monday for the first time since Sept. 12 after being sideline with Achilles tendinitis in both legs.

PFF grades from the San Francisco 49ers’ Week 8 win show it was a collective effort that lifted them over the Dallas Cowboys.

San Francisco 49ers rookie running back Isaac Guerendo’s coachability and maturity has played a big role in his steady development this season.

Matt Maiocco delivers the San Francisco 49ers’ report card from their Week 8 win over the Dallas Cowboys at Levi’s Stadium.

Deebo Samuel and Isaac Guerendo helped the 49ers make NFL history in San Francisco’s 36-24 win over the Seattle Seahawks last week.

Did rookie running back Isaac Guerendo intentionally go down before reaching the end zone on a 76-yard run late in the 49ers’ win in Seattle? No one in San Francisco’s locker room can agree.

49ers running backs coach Bobby Turner loves what he sees from rookie Isaac Guerendo so far in OTAs.

49ers rookie running back Isaac Guerendo is using his lack of usage in college as motivation at the NFL level.