San Francisco 49ers September 9, 2022 2:20 pm San Francisco 49ers 2022 Game Schedule Check out all the times, dates and locations the 49ers will play this 2022 season! Play and/or scroll through the video for the full schedule. US & World Videos 1:23 NFL draft prospects continuing family legacies 1:20 49ers open applications for ‘Follow Your Bliss' award 4:01 Recap: NFL season comes to an end with the Niners one step away from winning it all 2:05 49ers return to the Bay Area after Super Bowl loss 1:19 Watch: 49ers return to the Bay Area after Super Bowl loss