Best rushed for 131 yards and a school-record five touchdowns to lift the eighth-ranked Golden Bears to a 35-21 victory over scrappy Minnesota on Saturday.
Kevin Riley overcame a shaky start to finish with 252 yards for Cal (3-0), which had lost eight of its last nine on the road, including four in a row to end last season.
Eric Decker caught eight passes for 119 yards and two touchdowns and threw another TD for the Golden Gophers (2-1), who gave Cal everything it could handle in their shiny new stadium.
But Adam Weber threw a costly interception late in the game and Best had too much speed for the Gophers, who were in search of their first victory over a top-10 team at home since beating No. 1 Michigan in 1977.