Jeff Samardzija already shut down the Rockies at Oracle Park once this season, and he'll look to duplicate that Wednesday afternoon.
The Giants will hand the ball to the right-hander in the series finale against the Rockies, Colorado will counter with German Marquez.
After dropping the first game of the series, the Giants bounced back with a 4-2 win Tuesday night behind Madison Bumgarner's 11-strikeout performance.
Bruce Bochy's lineup will feature Brandon Belt back at the top, with the red-hot Alex Dickerson batting cleanup behind Pablo Sandoval.
Here are the full lineups for Wednesday's Giants-Rockies game at Oracle Park.
First pitch for Rockies-Giants is scheduled for 12:45 p.m. PT, with pregame coverage beginning at 11:30 a.m. You can follow all the action on NBC Sports Bay Area and streaming online and on the MyTeams app.
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San Francisco (34-44)
Brandon Belt, 1B
Mike Yastrzemski, RF
Pablo Sandoval, 3B
Alex Dickerson, LF
Stephen Vogt, C
Kevin Pillar, CF
Brandon Crawford, SS
Joe Panik, 2B
Jeff Samardzija, RHP (4-6, 4.23 ERA)
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Colorado Rockies (41-38)
Charlie Blackmon, RF
David Dahl, CF
Nolan Arenado, 3B
Daniel Murphy, 1B
Raimel Tapia, LF
Ryan McMahon, 2B
Tony Wolters, C
Garrett Hampson, SS
German Marquez, RHP (7-3, 4.32 ERA)