Eugenio Suarez hit a two-run homer during Cincinnati's seven-run third inning, and the Reds swept the San Francisco Giants with an 11-4 win on Sunday.
Jose Peraza also hit a two-run homer for Cincinnati, which outscored San Francisco 18-5 in the last two games of the weekend set. Billy Hamilton tripled twice and drove in three runs.
The Reds also swept the Giants in Cincy last season. Nine different Reds scored at least one run, helping Cincinnati bounce back after it was swept by Cleveland.
San Francisco dropped its fourth consecutive game. Andrew Suarez (4-9) was tagged for seven runs, five earned, and seven hits in a season-low 2 2/3 innings.
Giants infielder Chase d'Arnaud worked a scoreless eighth in his first career pitching appearance.
Suarez's 27th homer made it 6-1 in the third. Scooter Gennett hit a two-run triple before Suarez's drive to center.
Curt Casali also had two hits and drove in two runs in Cincinnati's big inning.
Reds right-hander Luis Castillo (7-10) struck out nine in 6 2/3 innings. He was charged with three runs, one earned, and six hits.
Castillo retired 13 straight batters before Stephen Duggar's two-out single in the seventh.
Peraza finished with three hits as Cincinnati closed out a 5-4 homestand. Phillip Ervin had two hits and scored a run.
Reds: OF Scott Schebler (strained AC joint in his right shoulder) is set for a rehab assignment with Double-A Pensacola. The Reds hope he will be ready to join them in Chicago during their weekend series with the Cubs.
Giants: LHP Derek Holland (6-8) makes just his second career start against the Mets in Monday's series opener in New York.
Reds: Homer Bailey (1-10) is scheduled to start Monday in Milwaukee. The Reds are 1-15 in Bailey's starts this season.