The San Jose Sharks' power play is starting to show some bite.
Setoguchi scored on a screened shot from the high slot.
"As soon as I got the puck I took a quick look at the net and saw traffic there," said Setoguchi, who also had an assist. "I figured I'd bury my head and just shoot as hard as I could. It found a hole and went in.
Dan Boyle scored two power-play goals for the Sharks, who went 4-for-6 with the man advantage. In their previous game, a 6-1 rout of Calgary on Thursday night in San Jose, the Sharks went 4-for-9.
Milan Michalek, Joe Thornton and Jeremy Roenick also connected to help NHL-leading San Jose win its second straight to improve to 9-1-1 in its last 11.
Although the Sharks lead the NHL with 31 points, they entered Sunday's game with an 18.8 power-play conversion rate -- only 14th best.
"Against Calgary it was 4-for-something, too," Setoguchi said. "Lately we're starting to get shots and pucks are going in for us."
"The power play has been pretty good the last couple of nights," added San Jose goalie Brian Boucher. "We have the guns, there's no question. If we keep doing what we're doing -- getting point shots and spreading things out - it's hard to defend.
San Jose's Joe Pavelski had three assists.
Both San Jose and Chicago players and coaches remarked about a rough ice surface that led to bouncing pucks and miscues.