The Oakland Raiders were missing a couple of key players on offense Sunday, but it was their lagging defense that led to their demise in a 42-21 loss to the Tennessee Titans.
Ryan Tannehill threw for 391 yards and three touchdowns and Derrick Henry ran for two scores as the Titans won their fourth straight game.
The Titans (8-5) bounced back from a deflected interception on the opening drive to score TDs on five of their next seven possessions to improve to 6-1 with Tannehill as the starting quarterback.
The win moved them into a tie for first place in the AFC South with Houston, with the teams set to meet twice in the final three weeks.
Tennessee broke open a tight game with a three-touchdown barrage in a span of just over seven minutes of the second half that all but ended the playoff hopes for the Raiders (6-7) in their final season in Oakland.
Henry, who rushed for 103 yards, broke a 21-all tie with a 10-yard TD run midway through the third quarter to cap an 89-yard drive.
The Raiders then went three-and-out on their next drive and Tannehill easily drove Tennessee 84 yards for a 35-21 lead on a 17-yard pass to Jonnu Smith.
The boo birds then came out in the second-to-last game at the Coliseum when Darren Waller fumbled a catch after a hit by Tye Hill and Jayon Brown returned it 46 yards.
What had been a promising season for the Raiders with a three-game win streak in November that improved them to 6-4 has gone off the rails the past three weeks. They lost by 31 points in successive road games against the Jets and Chiefs and then fell apart in the second half against Tennessee. This marked just the second time in franchise history that Oakland dropped three in a row by at least 21 points, having also done it in 2012.
Tannehill threw two TD passes in the first half to rookie A.J. Brown, including a 91-yarder. Brown finished with five catches for 153 yards.
Tennessee finished with 552 yards, their second most since the merger in 1970. They had 563 in a 27-10 win over Kansas City on Dec. 16, 1990.