After a week of concern over whether he would make his 83rd straight start, Manning threw two scoring passes and led the Giants on touchdown drives on their first four series in a 44-7 win that has New York (5-0) off to its best start since winning the Super Bowl in 1990.
Oakland quarterback JaMarcus Russell lost three fumbles and was sacked six times as the Raiders' league-worst offense was limited to 124 yards. Russell was 8 of 13 for 100 yards.
Michael Bush scored on a 5-yard touchdown run, a drive set up when the Giants' Sinorice Moss fumbled on a punt return at his 15.
Manning tossed touchdown passes of 30 yards to Mario Manningham and 9 yards to first-round draft pick Hakeem Nicks. He finished 8 of 10 for 173 yards before donning a baseball cap late in the second quarter for a well-deserved rest on a day the Giants gained 483 yards in total offense.
Backup halfback Ahmad Bradshaw ran for 110 yards and scored on runs of 1 and 9 yards. David Carr, who replaced Manning, scored on a 12-yard scramble and Lawrence Tynes added three field goals.
Manning's availability was the Giants' biggest concern all week against Oakland (1-4). He sustained a painful injury to his right heel in the win over Kanas City last weekend. The 2008 Super Bowl MVP missed two days of practice and then took half the snaps Friday, giving the indication he would go on Sunday.
The Raiders return home next Sunday to face another NFC East team, the Philadelphia Eagles.