The A's had a chance to take a road series against the top team in the league, but the Astros' deep lineup continued to be too much Thursday in a 6-1 loss.
Daniel Gossett took the loss after allowing five earned runs in five innings pitched.
On offense, the A's went silent and only put together five hits.
Carlos Correa stole the show with two home runs and four RBI.
The A's are now 35-44 on the season.